Self-serve preclinical testing

The lab is now an API

Specify a study. Provision it. Pay online or via API. VivoProof runs the preclinical testing — automated, programmable, and continuously improving. No sales calls. No six-week quoting cycles. Just structured data back.

Start Proof Planner See how it works

EVIDENCE PACKAGE · study_brief.v0.3 feasibility-reviewed

claim: "CNS candidate — target engagement + exposure"
material: lot VP-2291-A · COA ✓ · SDS ✓
system_tier: in vitro → ex vivo
n_per_arm: 8
timepoints: 0, 4, 24 h
route: in vitro incubation
endpoints: potency (IC50), selectivity, viability, exposure
planning_range: 5–10 business days
status: scoped

04 BIOANALYSIS / PK-PD
03 IN VIVO
02 EX VIVO / ORGANOID
01 IN VITRO

Animal work not first — cheapest credible system that answers the claim.

Capability, not vanity

04 System tiers — in vitro · ex vivo · in vivo · bioanalysis
24/7 Specify and provision studies anytime — no sales calls
100% Welfare-reviewed before execution — IACUC compliant
JSON Structured data returned — CSV, XLSX, and API

01 The gap

Discovery got fast. Testing didn't.

AI-native teams generate candidates in weeks, then wait months for preclinical testing they can't provision programmatically. VivoProof is the lab — automated and API-accessible. Specify a study, pay for it, and it starts. The platform gets smarter with every order.

before idea → sales call → quote → wait → PDF

with VivoProof molecule + claim → API → structured data

02 Evidence ladder

Cheapest credible system first. Animal work only when it's the right proof.

The platform returns a laddered plan. Cost and invasiveness escalate as you climb — nothing goes in vivo until an in vitro or ex vivo system genuinely can't resolve the claim.

01
In vitro

Potency, selectivity, viability, exposure-response.
receptor · cell · biochemical
02
Ex vivo / organoid

Explant, tissue-context, formulation, stability.
organoid · explant · matrix
03
In vivo

Tolerability, PK/PD, disease-model, histology.
welfare-reviewed · IACUC
04
Bioanalysis / PK-PD

LC-MS/MS, exposure tables aligned to endpoints.
plasma · tissue · exposure

cost / invasiveness increases left → right · the ladder starts at the bottom rung that can honestly answer the claim

03 The stack

One operating stack, six named layers.

L1
Proof Planner

Scope a vague claim into a plan and a planning range.

claim → plan
L2
Evidence Ladder

Order the systems cheapest-credible-first, animal work not by default.

in vitro → bioanalysis
L3
Protocol Assumptions

Fix groups, timepoints, route, and endpoints before any quote.

n=8 · 0,4,24h
L4
Automated Execution

VivoProof runs the scoped protocol in-house — automated, tracked, and continuously improving.

protocol → lab → data
L5
Execution Monitor

Track status from scoped through reported, deviations logged.

running
L6
Evidence Data Room

Deliver a reusable structured package, not a PDF.

report + tables + manifest

The lab is an API

Provision a study in one call.

POST your protocol. VivoProof runs it. You get structured data back — endpoint tables, sample maps, exposure data, and deviation notes. Machine-readable, not a PDF. Built for agents, pipelines, and 2am research sessions alike.

Try Proof Planner first

create_study.sh200 OK

curl -X POST https://invivoapi.com/api/create-study \
  -H "Authorization: Bearer $VIVOPROOF_KEY" \
  -H "Content-Type: application/json" \
  -d '{
    "study_ref": "vp-cmpd-0429",
    "molecule": "custom CNS candidate",
    "claim": "target engagement + exposure",
    "system_tier": ["in_vitro", "ex_vivo"],
    "n_per_arm": 8,
    "timepoints_h": [0, 4, 24],
    "route": "in_vitro_incubation",
    "endpoints": ["ic50", "selectivity", "viability"]
  }'

"study_id":    "vp-2026-0429-A",
"status":      "provisioned",
"planning_range": "5-10 business days",
"tracking_url": "invivoapi.com/study/vp-2026-0429-A"

04 Execution

Status you can read at a glance.

Every run is tracked against the approved assumptions, and every deviation is logged. When the answer is no, the system says so — negative results are recorded in plain, auditable notes.

specified provisioned welfare-reviewed running reported

2026-06-18 09:14＋ arm B n=8 acclimation complete

2026-06-18 14:02timepoint t=4h samples collected · chain-of-custody logged

2026-06-19 11:37△ deviation: t=24h read +35 min — logged, within window

audit-trailchain-of-custodydeviation-loggedfeasibility-gated

No sales calls

Specify. Provision. Pay. Done.

VivoProof is the lab. There's no marketplace, no provider matching, no quote negotiation. You design the protocol in Proof Planner or via API, confirm a card to unlock your exact price, pay, and the study starts. Every step is tracked, and the platform gets faster with every order.

Self-serve pricing in Proof Planner — no sales calls, no negotiation
API access for programmatic study provisioning
Status tracking via dashboard or webhook
Structured data delivered as CSV, XLSX, and JSON

1. Specify

Proof Planner
or API

2. Provision

Pay online
or via API

3. Study starts
Track via dashboard
Structured data back

05 The deliverable

The data package is the product.

A reusable Evidence Data Room — a narrative report, raw endpoint tables, a sample map, deviation notes, and explicit caveats. Standardized, machine-readable, and just as rigorous when the result is negative.

endpoint_tables.csv

arm	n	t (h)	IC50 (nM)	viab %
vehicle	8	24	—	98.2
cmpd-lo	8	24	412	96.1
cmpd-hi	8	24	38	91.7

sample_map

S-001 plasma · t0 · −80°C
S-014 tissue · t4 · fixed
S-027 plasma · t24 · −80°C
S-031 tissue · t24 · fixed

deviation_notes

△ t=24h read +35 min — within window, no impact on endpoint.

result: exposure-response confirmed in vitro; ex vivo pending.

manifest.json

{
  "package": "VP-2291-A",
  "files": 6,
  "formats": ["pdf", "csv", "xlsx"],
  "reusable": true
}

One layer, three ways in

The same evidence engine, read three ways.

AI drug discovery teams
Your agent found a candidate. Your agent can commission the study — via API.
POST /studies → 200 OK
Biotech startups
From molecule to evidence plan in minutes. Pay online, track via dashboard.
no lab ops · self-service
Supplement & peptide brands
Third-party validation that survives scrutiny. No lab relationship required.
independent · structured

Built for the builder

"I designed the protocol at midnight, paid online, and the study started the next morning. No sales calls, no negotiation, no waiting. I got structured endpoint tables back — not a 200-page PDF that nobody reads."

Founder, independent small-molecule program representative builder · named on request

06 Methods & network

Methods updates and network changes.

2026-06-18 Automated organoid-tier endpoint templates added to the pipeline. automation · v0.6
2026-05-30 PK/PD bioanalysis pipeline expanded — faster turnaround on exposure data. pipeline · v0.5
2026-04-22 API v0.3: webhook notifications for study status changes. api · v0.3

Self-service first

Don't call us. Use the planner.

The fastest path is Proof Planner — design your protocol, confirm a card to unlock real pricing, and provision the study yourself. If you need help scoping a complex program, send context below and we'll respond by email. No calls required.

Self-serve pricing in Proof Planner — no sales calls, no negotiation
API access for programmatic study provisioning
COA, SDS, and material quantity requested during intake